摘要
6名健康志愿者静脉滴注乳酸环丙沙星200mg/h,以反相高效液相法测定其血,尿中药物浓度,井据此计算有关药动学参数.静脉滴注结束时即刻血浓度为3.84±0.35μg/mlT1/1β为328h,Vd为1.54L/kg,AUC为10.12mgh/L。静滴环丙沙星200mg后24h内,尿中药物排出量占给药量的78.94%,说明该药主要由肾肚清除。
n this study, the reverse- pliase HPLC was used to determine the serum and urine concen- tration of ciprofloxacin in 6 healthy volunteers during and after a 60-minute intravenous infu-sion of 200mg of its lactate. The compartnient model was determined by F value,r ̄2 and AIC.Theserum drug concentration-time profile conformed to the two-compartment open model. Afterintravenous infusion,the peak level was 3.84 ± 0.35ug/ml.The elimination half-life, the apparentvolume of distribution and the area under the serum concentration curve were 3. 28h,1. 54L/kgand 10. 12mg.h/L,respectively. After a 60-minute intravenous infusion of 200mg ciprofloxacin lactate,the urinary recoveryrate winthin 24h was 78.94% of administered dose and this indicates that this drug is eliminatedmainly from the kidney
出处
《重庆医科大学学报》
CAS
CSCD
1995年第4期254-257,共4页
Journal of Chongqing Medical University