165例慢性肝炎临床与病理分析

Clinical and pathologic Studies On 165 Cases of Chronic Hepatitis

本文对165例肝活检证实的慢性肝炎进行临床与病理诊断对比分析。临床诊断慢性活动性肝炎76例,病理诊为慢性活动性肝炎62例,其余14例为慢性迁延性肝炎,符合率81.6%。临床诊断为慢性迁延性肝炎69例、病理诊断慢性迁延性肝炎41例,其余28例为慢性活动性肝炎,符合率59.4%。慢性活动性肝炎组ALT、AST、球蛋白显著高于慢性迁延性肝炎组(p＜0.01)。慢性活动性肝炎的凝血酶原活动度(PTA)明显低于慢性迁延性肝炎(P＜0.01),慢性活动性肝炎组HBV复制标志较慢性迁延性肝炎组高(p＜0.01)。提示慢性活动性肝炎复发与病毒复制有关,结果显示临床与病理有明显的不一致性,并对差异的原因进行了讨论。

165 cases of chronic hepatitis (confirmed by liver biopsy) were comparatively studied in clinical and pathologic diagnosis. 62 of 76 cases clinically diagnased as chronic active hepatitis (CAH) were pathologically diagnosed as CAH, the others were chronic prolonged hepatitis (CPH). The coincidence rate was 81.6%. 41 of 69 cases clinically diagnosed as CPH were pathologic CPH, the others were CAH. The coincidence rate was 59.4%- ALT. AST and golbulin were significantly higher in CAH group than in CPH group (p<0. 01). Prothrombin Activity of CAH was distinitly lower than that of CPH (p<0. 01). HBV replication marker was more high in CAH (p<0. 01). IT implied that virus replication was responsible for CAH recurrence. The results showed there was an apparent discordance in clinic And pathology. The cause of difference were discussed.