慢性肺心病急性发作期患者血清类洋地黄因子含量变化的意义

SIGNIFICANCE OF sEDF IN CPHD PATIENTS IN ACUTE ATTACK STAGE

采用放免法测定60例慢性肺心病急性发作期患者血清类洋地黄因子含量。结果表明，该病患者的血清类洋地黄因子含量比正常人显著升高（P＜0．0001），且其含量随患者右心功能不全加重而递增，经治疗后其含量降低（P＜0．0001）．提示血清类洋地黄因子含量的变化可反映出患者的病情轻重和右心功能状态，并可作为估计洋地黄药物治疗剂量的参考指标之一．

The Serum levels of Endogenous Digitalis like Factor (sEDF) were measured by RIAin 60 Patients With Chronic Pulmonary Heart Disease (CPHD) in acute attack stage. The resultsshow that sEDF increased significantly in CPHD group (P<0. 0001). Besides, the Patients' levels ofsEDF increased with the increase of severity of Congestive Heart Failure (CHF). After treatment thequantity of sEDF in the patients decreased obviously (P<0. 0001 ). It is concluded that the levels ofsEDF can reflect the Severity of the disease and the functional state of right heart. It can be used as areference index for assessing the digitalis dosage.