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二硫化碳肾脏毒性研究

STUDY ON THE NEPHROTOXICITY OF CARBON DISULFIDE
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摘要 为探讨二硫化碳(CS_2)对大鼠的肾脏毒性,3个染毒组分别以50,250,1250mg/m ̄3的浓度静式吸入CS_2,每天2h,每周6天,连续8周,并与对照组比较。结果:1、各染毒组尿γ-GT、AKP活性、尿β_2-MG含量,大、中剂量组尿LDH活性、尿Alb含量,以及大剂量组尿IgG、总蛋白含量、血BUN含量均较对照组显著增高;2、光镜检查发现肾小管上皮细胞浊肿、空泡变性、肾小球肿大;电镜下见基底膜紊乱、线粒体肿胀、嵴断裂等;3、肾皮质小管中AKP、ATPase、SDH、ANAE酶活性下降,以AKP,SDH活性下降最为明显。 Nephrotoxicity of carbon disulfide was studied through subchronic toxicity test in rats.48 healthly Wistar rats weighting 200±20gwere randomly divided into 4 groups, each with 6 males and 6 females. 3groups of rats were exposed to CS2 of 50, 250, 1250mg/m3 respectively by means of inhalation in a close box, 2 hours daily, and 6 days a week for 8 consecutive weeks. The results showed: 1 , urinary γ-GT, AKP, β2-MG in all inhaled groups, urinary LDH, Alb in high and middle dose groups and urinary volume,IgG, protein, blood BUN in high dose group of treated rats were significantly increased compared with control (P <0.05 or P<0.01). 2, microscopy revealed that the cells of proximal tubules were cloudy swelling and vacuolar degeneration and glomerular enlarged. Electronic microscope examination found disorders of basement membrane of the epithelium proximal convouluted tubules, mitochondria swelling and disappearance of matrical density of the cristae. 3, the activity of AKP, ATPase, SDH, ANAE decreased in the proximal tubules compared with the control, particularly the activity of AKP and SDH was greatly decreased.
出处 《山东医科大学学报》 1995年第2期134-138,共5页 Acta Academiae Medicinae Shandong
关键词 二硫化碳素 尿 组织化学 肾脏毒性 Carbon disulfide Urine Kidney Histocytochemistry Microscopy Microscopy, electron
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