胆石病胆囊淋巴细胞亚群分布的观察

DISTRIBUTION OF LYMPHOCYTE SUBPOPULATION IN PATIENT'S GALLBLADDER WITH CHOLELITHIASIS

应用ＯＫ系列单克隆抗体和免疫组化技术，对正常胆囊和胆石病患者胆囊中淋巴细胞亚群的数量、分布及其比例关系进行了观察和分析。结果表明，正常胆囊仅有少量各型淋巴细胞亚群散在分布，Ｔ淋巴细胞占多数；胆石病胆囊中各淋巴细胞亚群数量显著增加，ＴＨ细胞、Ｂ细胞和ＩｇＡ＋细胞增加最多，细胞免疫及体液免疫均显著增强，以体液免疫明显。提示胆石病患者胆囊损害、纤维化及胆石形成可能与胆囊各淋巴细胞亚群间比例失调及分布变化有关。

The amount, distribution and proportion of lymphocyte subpopulation in the normal gallbladder and patient's gallbladder with cholelithiasis was studied by immunohistochemical techniques. The results showed that 1,A few lymphcytes subpopulation were distributed in the normal gallbladder, T-lymphocytes dominated in the amount,2, the total amount of lymphocyte subpopulation in the cholelithiasis gallbladder was greatly increased, 3 , both cell-mediated immune and humoral immune responses in cholelithiasis gallbladder were strengthened significantly, especially the latter one. There were the disproportion among lymphocyte subpopulation and abnormal distribution of lymphocyte subpopulation. These changes Were possibly related to gallbladder damage, fibrosis and cholelithes formation.