静脉注射大剂量维生素C的药代动力学研究

THE PHARMACOKINETICS OF HIGH-DOSE VI,TAMINE C AFTER INTRAVENOUS INJECTION

本文报告单次静脉注射大剂量维生素Ｃ的药代动力学研究。采用改进后的高效液相色谱法测定血清维生素Ｃ浓度。９例成年受试者单次静脉注射维生素Ｃ１０ｇ后的药时曲线经非线性最小二乘法自动拟合，符合二室开放模型。平均药时方程是Ｃ＿１＝６８０．０２２４￣（－０．６４６４６ｔ）＋２８．７８６８￣（－０．０４４ｔ）。主要动力学参数为ｔｌ／２ａ＝１．１０±０．１７ｈ，ｔｌ／２β＝１７．６７±６．３ｈ，Ｖｃ＝１４．４８±２．３ｌ，Ｖ２＝１３１．４３±４２１。并对实验结果的临床意义进行了讨论。

n improved High Performance Liquid Chromatographic Method for determination of vita-mine c in serum was used. The pharmacokinetics of high-dose vitamine c was studied in 9adults after intravenous injection of a dose of 10g。 The data were fitted by nonlinear regressionautomatic program and proved to be,ubjected to two compartment open model. The serum con-centration-time equation vyas Ct=680. 0224￣(0.646t)+28. 7868￣(0.044t). The pharmacokiontic parameterswere:t1/2a=1.1±0.17hr,t2/2β=17.67±6.3hr,Vc=14.48±2.31,V2=131. 43±421.The clinical im-plications of results are discussed。