扩张型心肌病细胞免疫的初步研究

Preliminary Study of Cellular Immunological Mechanism inIdiopathic Dilated Cardiomyopathy

本文应用免疫酶标染色法及微量细胞毒试验分别检测了扩张型心肌病（ＤＣＭ）外周血Ｔ淋巴细胞亚群ＣＤ３、ＣＤ４及ＣＤ８及自然杀伤细胞活性（ＮＫ），并与正常对照组（ＮＣ）比较，结果发现ＤＣＭ患者的ＣＤ８明显低于ＮＣ组（Ｐ＜０．０１），而ＣＤ４／ＣＤ８比值高于ＮＣ组（Ｐ＜０．０５）；同时发现ＮＫ活性低于ＮＣ组（Ｐ＜０．００１）．因此推测Ｔ淋巴细胞亚群异常及ＮＫ活性缺失所致的细胞免疫功能紊乱可能是ＤＣＭ发病的因素之一。

Idiopathic dilated cardiomyopathy(DCM)is a disease in which immune aberration has beenpostulated but not confirmed.The frequency of peripheral blood T-lymphocyte subsets(CD3,CD4 and CD8)was evaluated in 30 patients with DCM and 20 normal control(NC) subjects.In the meanwhile,the naturalkiller cell(NK)activity was also studied in 20 patients and 24 NC subjects. It showed that①The percentageof CD8 cells was significantly loweier in DCM than in NC(P<0.01).②The NK cytotoxicity was statisticlylower in DCM than in NC(P<0.001).The results suggested that the cellular immunological disorders may bean important part of pathogenesis of DCM.