摘要
不同浓度一氧化碳对大鼠脂质过氧化及各胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的影响研究结果表明：大鼠在５００ｍｇ／ｍ３ＣＯ染毒下，第２０天血液中的脂质过氧化物及第３０天心脏组织的脂质过氧化物均明显升高，而５０、２５ｍｇ／ｍ３ＣＯ染毒则未见上述变化。但自２５ｍｇ／ｍ３浓度开始，ＧＳＨ－Ｐｘ活性即发生明显变化。提示ＣＯ能诱发自由基导致脂质过氧化；也说明ＧＳＨ－Ｐｘ是ＣＯ对机体影响的早期敏感指标之一。本研究可为室内ＣＯ卫生标准的制订提供部分新的资料。
In this paper,we observed the effects of CO at low concentration on lipid peroxidation and glutathione peroxidase (GSH-Px).The results showed that the lipid peroxide (MDA)in plasma increased significantly when rats exposed to 500mg/m3 CO for 20 days and so was in its heart tissue for 30 days,the changes mentioned above for 50,25mg/m3 CO were not observed,but 25 mg/m3 CO caused the changes of GSH-Px. These results indicated that CO can induce free radical,then form lipid peroxide;and suggested that GSH-Px was a early sensitive index about the effects of CO. The results could be used ad the new evidence in setting up indoor air CO criterion.
出处
《环境与健康杂志》
CSSCI
CSCD
北大核心
1995年第3期111-114,共4页
Journal of Environment and Health
基金
卫生部标准委员会资助
关键词
一氧化碳
脂质过氧化
GSH-PX
大鼠
Carbon
Monoxide
Lipid peroxidation
Glutathione
Peroxidase
Free radical
