摘要
超氧化物歧化酶(SOD)对小鼠和大鼠角叉菜胶足跖肿胀、大鼠巴豆油肉芽肿胀及佐剂关节炎肿胀等有明显抑制作用;具有保护环磷酰胺对小鼠降低白细胞的作用;对小鼠腹膜通透性有明显降低作用。SOD 毒性甚小,小鼠静注 LD_(50)为4.461g/kg。
Superoxide dismutase(SOD)has an obvious suppressing effect on the cerrageenan inducing foot-
edema of mice and rats,croton oil inducing granulation tissue edema of rats,and arthritis induced
by Freund's adjuvant etc.It also has protective effect on cyclophosphamide inducing leukopenia to
mice and a clear reducing effect on permeability of peritonium of mice.SOD has little toxicity.
LD50(iv)to mice is 4.461 g/Kg.
关键词
超氧化物歧化酶
药效学
不良反应
Superoxide dismutase(SOD)
Pharmacodynamics
Adverse Reaction
