摘要
用四氧嘧啶诱发糖尿病兔模型，以观察糖尿病兔角膜神经分布的形态学改变。试验兔分别于６、８、１０、１２周各处死一批，用组织化学技术和透射电镜观察兔角膜神经的分布、形态和结构改变。结果发现，糖尿病兔自造模后６周，神经网丛密度明显稀疏，神经分支变细，神经活性降低。超微结构显示，糖尿病兔角膜神经轴突肿胀，其内神经原纤维分布不均，线粒体呈现不同程度的变性。随着病程延长，上述变化日趋明显，推测糖尿病时角膜神经的改变与高血糖引起的代谢紊乱有关。
he morphology of corneal innervation
was studied in rabbits with alloxan-induced diabetes. The
experi-mental rabbits were killed at 6,8,10,12 weeks,respectively.
Corneal innervation was studied with histo- chemical techniques and
transmission electron microscopy.The results revealed that in
diabetic rabbits, from6 weeks,the density of nerve-nets was markedly
sparser,and the fibers were thinner.The activity of nerveswas lower
than that of control group.Ultrastructural changes included swelling
of axons,irregular distribu-tion of fibrils and degeneration of
mitochondria of varying degree. The changes above were severe with
vary- ing degrees with prolonged experiment phase. We assume that
hyperglycemia is responsible for thesechanges.
出处
《眼科研究》
CSCD
1995年第3期145-146,共2页
Chinese Ophthalmic Research
