关附己素对麻醉大鼠血流动力学的影响

HEMODYNAMIC EFFECTS OF GUAN-FU BASE F IN ANBSTHETIZED RATS

研究了关附己素（１０ｍｇ·ｋｇ^（－１），ｉＶ）和普罗帕酮（４ｍ９·ｋｇ^（－１），ｉＶ）对麻醉大鼠血流动力学的影响。结果表明，关附己素与普罗帕酮均可显著延长大鼠心电图Ｐ－Ｐ间期、Ｐ－Ｒ间期、ＱＲＳ波群以及Ｑ－Ｔ间期。而前者的作用时间更为持久。本品可显著抑制ＨＲ、±（ｄｐ／ｄｔ）ｍａｘ和（ｄｐ／ｄｔ）·ｐ－１ｍａ＝ｘ，但不影响ＬＶＳＰ、ＬＶＥＤＰ。关附己素对ＳＡＰ无影响，但对ＭＡＰ和ＤＡＰ有明显的一过性降低作用。而普罗帕酮除对ＬＶＥＤＰ无影响外，对上述所有参数均有显著抑制作用。上述结果提示，关附己素可抑制心内冲动传导，对心率抑制较强，且延长心舒张期，而对动脉血压影响较小。

The hemodynamic effects of guan-fu base F(GFF) nd propa fenone were investigated in anesthetized rats.Although both drugs Significantly prolonged the P-P interval.P-R interval,QRS complex and Q-T interval,the effects of GFF(10 mg·kg-1,iv) n P-P interval and P-P interval remained longer than that of propafenone(4 mg·kg-1,iv).Meanwhile,GFF markedly decreased HR,±dP/dtmax and(dP/dt).with insignificant changes in LVSP and LVEDP.MAP and DAP were reduced temporarily and reversed quickly,but SAP was not affected.However,propafenone produced significant depress ion in all parameters above-mentioned,except LVEDP,The results showed that GFF inhibits ntracardiac impulse conduction and HR,and it increases the diastolic period.The blood pressure was affected slightly.