摘要
建立兔脑ＭＣＡＯ局部脑缺血实验模型。用生化方法分别测定Ｎａ＋，Ｋ＋－ＡＴＰ酶和Ｃａ２＋，Ｍｇ２＋－ＡＴＰ酶活性。并行体感诱发电位（ＳＥＮ及经颅多普勒超声检查（ＴＣＤ）。结果发现：脑缺血早期Ｎａ２＋，Ｋ＋－ＡＴＰ酶活性迅速下降，Ｃａ２＋，Ｍｇ２＋－ＡＴＰ酶略有下降。ＳＥＰ的Ｎ１波、Ｐ２波的潜伏期明显延长。ＴＣＤ检查中，ＭＣＡＯ侧不能测出波形，而对侧平均流速（Ｖｍ）显著增快，再通后ＭＣＡ波型立刻恢复。
The activities of Na+and K+-ATPase and Ca and Mg -ATPase and the changes of somatosensory evoked potentials(SEP)and transcranial Doppler sonographs(TDS)were studied on a rabbit model of middle cerebral artery occlusion(MCA-O).It was found that Na+ and K+-ATPase activity was decreased immediately but no significant reduction of Ca and Mg -ATPase activity was observed.The latency of N1 and P2 waves was significantly prolonged and TDS showed no ipsilateral wave after MCA-O and the mean velocity of blood flow in the contralateral MCA was inncreased.After reperfusion,the wave of the preocluded artery was restored.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1995年第3期220-222,共3页
Journal of Third Military Medical University
关键词
脑缺血
ATP酶
脑组织
超声波
诱发电位
animal model
somatosensory evoked potential
transcranial Doppler sonography
ATPase
