锌对呼吸道内皮素的影响

Effects of zinc on endothelin of respiratory tract in rats

通过缺锌（ＺＤ）、过量锌（ＺＥ）动物模型观察锌对大鼠呼吸道灌洗液中及血浆内皮素（ＥＴ）含量的影响。结果表明：（１）ＺＤ组大鼠支气管肺泡灌洗液中的ＥＴ、肿瘤坏死因子（ＴＮＦ）、一氧化氮（ＮＯ）和肺巨噬细胞杀菌力（ＢＡ）均低于自由喂养（ＡＬ）组（Ｐ＜０．０５或Ｐ＜０．０１）。ＺＥ组的ＮＯ和ＢＡ也低于ＡＬ组（Ｐ＜０．０１）。（２）ＺＤ组大鼠血浆ＥＴ、ＴＮＦ、ＮＯ均低于ＡＬ组（Ｐ＜０．０１）。ＺＥ组血浆ＴＮＦ和ＮＯ也低于ＡＬ组（Ｐ＜０．０１或Ｐ＜０．０５）提示缺锌可致支气管肺泡和血浆ＴＮＦ、ＮＯ减少，肺巨噬细胞杀菌活力减弱。

The effects of zinc on the endothelin level of the respiratory organs were observed in zinc deficient(ZD),zinc excessive (ZE) and adequate libitum(An) groups of rats. The findings were as follow:(1)The level of endothelin(ET),tumor necrosis factor(TNF) and nitrogen monoxide(NO ) and the bacteriocidal capacity of the phygocytes in the broncholaveolar lavage fluid(BALF) were lower in ZD group than in AL group(P<0. 05 or P <0. 01 ), The NO level and bacteriocidal capacity of the phagocytes in BALF were also lower in ZE group than in AL group(P<0.01). (2)The plasma level of ET,TNF and NO was lower in ZD group than in AL group( P < 0.01).The plasma level of TNF and NO was lower in ZE group then in AL group. These findings indicate that adequate amount of zinc in the diet contributes greatly to the bacteriocidal capacity of the phygocytes and synthesis of ET,TNF and NO in the respiratory organs。 Consequently plasma and BALF levels of ET and BALF Ievels of TNF and NO are decreased and the bacteriocidal capacity of pulmonary phagocytes is suppressed in ZD and ZE rats.