摘要
本文报道了犬肝动脉灌注甲氨蝶呤（ＭＴＸ）明胶微球后的血药浓度变化，以及大鼠肝动脉灌注１２５Ｉ－ＭＴＸ明胶微球后的体内分布，结果表明，动物肝动脉灌注ＭＴＸ明效微球后，微球主要集中在肝区，且缓慢释放药物。
This paper reports the results of determination of plasma levels of methotrexate(MTX) in dogs after hepatic arterial perfusion of methotrexate gelatin microspheres (MTX-ms) and drug distribution in rats after the same route perfusion of ￣125I-MTX-ms.The results showed that most of the microspheres gathered in liver. Meanwhile, the drug entrapped in the microspheres could be released continuously.
出处
《中国药房》
CAS
CSCD
1995年第2期7-8,共2页
China Pharmacy
关键词
甲氨蝶呤
微球
药代动力学
methotrexate
microsphere
pharmacokinetics
