摘要
本文探讨了镧氨羧络合物ＩＬａＤＣＴＡ、Ⅰ－ＬａＮＴＡ和Ⅰ－ＬａＥＤＴＡ对荷Ｓ＿（１８０）肿瘤小鼠红细胞免疫粘附肿瘤细胞能力、红细胞内ＳＯＤ酶活及不同器官中丙二醛（ＭＤＡ）含量的影响。发现Ⅰ－ＬａＤＣＴＡ能促进红细胞粘附肿瘤细胞的能力，而Ⅰ－ＬａＥＤＴＡ、Ⅰ－ＬａＮＴＡ则起抑制作用；对ＳＯＤ酶活及ＭＤＡ含量也因络合物化学结构的不同结果各异。
The effects of Lanthanum polyaminocarboxylate complexes on the biological activity of tumor-bearing mice was studied,These compounds are Ⅰ-LaDCTA,Ⅰ-LaNAT,and Ⅰ-LaEDTA.We observed the action of red cell immune adherence and superoxide dismutase(SOD)activity,and the contents of malondialdehyde (MDA)in liver,spleen and thymus in S_(180) tumor-bearingmice.We found that Ⅰ-LaDCTA could promote the activity of red cell immune adherence to tu-mor cells,but Ⅰ-LaEDTA and Ⅰ-LaNTA inhibited it;the SOD activity and contents of MDAchange with the structural differences of the compounds.
出处
《甘肃科学学报》
1995年第2期46-49,共4页
Journal of Gansu Sciences
关键词
镧氨羧络合物
红细胞免疫粘附
抗癌药
生物活性
Lanthanum polyaminocarboxylate complexes
Red cell immune adherence
Superoxide dismutase(SOD)
Malondialdehyde (MDA)
