结直肠癌中雄激素受体及其与临床病理学特征关系的研究

The Study on the Androgen Receptor in Colorectal Adenocarcinoma

应用放射性配基结合分析法，检测了４０例结直肠癌及部分癌旁正常粘膜组织中的雄激素受体（ＡｎｄｒｏｇｅｎＲｅｃｅｐｔｏｒ，ＡＲ），同时分析了ＡＲ水平与临床病理学变化的关系。证实结直肠癌ＡＲ数目（３３．７±２３．３ｆｍｏｌ／ｍｇ蛋白）明显低于癌旁５ｃｍ以外粘膜（５３．９±３２．４ｆｍｏｌ／ｍｇ蛋白），Ｐ＜０．０１，而其亲和力则无变化；结直肠癌时ＡＲ数目变化与女性、直肠癌、高分化癌及早期癌关系密切。提示ＡＲ与结直肠癌关系密切，本实验为临床上结直肠癌的诊断及内分泌治疗提供了初步资料。

Androgen receptors(AR)in cancer tissue and adjacent normal mucosa in 40 patientswith colorectal adenocarcinorna were measured by radioligand binding assay(RLBA),and the re-lationship)between AR and the clinicalpathological changes in these patients was investigated me-anwhile.The following results were obtained:The amount of AR in colorectal carcinorma(33.7士23.3 fmol/lng.protein)were less than that of normal mucosa adjacent 5cm away from thecarcinoma(53. 9±32.4 fmol/mg.protein,but the affinities were similar;the difference of ARnumber in carcinoma and normal mucosa was closely related to female. Rectal neoplasms withhigher and earlier Dukes′stage. The data indicated that AK play an important role in colorectalcarcinoma,grade and set a basis for clinical diagnosis and endocrine therapy of colorectal cancers.