伴中枢神经系统病变的重症系统性红斑狼疮的治疗探讨

A study on the treatment of severe systemic lupus erythematosus with centralnervous system involvement

伴中枢神经系统（ＣＮＳ）受累的多脏器病变的重症系统性红斑狼疮（ＳＬＥ）治疗难度大。我们对７例患者应用大剂量皮质激素超过１月，早期予以环磷酰胺（ＣＴＸ）冲击治疗。病情缓解后中等剂量皮质激素维持半年以上，并继续静脉或口服免疫抑制剂。整个治疗过程中辅以抗精神病药、转移因子、中药、Ｈ２受体拮抗剂和升血药物治疗。由于有计划、有步骤地实施治疗方案，使患者获得满意的近、远期疗效，提高了重症ＳＬＥ有存活率。

Generally,treatment severe systemic lupus erythematosus(SLE)with involvement of central ner-vous system(CNS)and multiple organs is very difficult,We have treated 7 cases with high-dose of glucocor-ticoids administered for more than one month in comhination with intravenous“pulse”of cyclophosphamidegiven in the early stage. After patients being improved,moderate doses of glucocorticoids were maintaind formore than six months and immunosuppressive agents(Oral or IV)were continued to be given,Antipsy-chotics,lymphocyte-transfer factors,traditional Chinese medicine,H2-receptor antagonists and hematopoiet-ics were given as adjunct therapies when indicated.This planned therapeutic program has met satisfactoryshort and long-term effects.