摘要
本文观察了γ─氨基丁酸能B受体(GABAB)激动剂氯苯氨丁酸和γ─羟基丁酸对大鼠皮层脑电和行为的影响。腹腔注射氯苯氨丁酸(2和4mg/kg)诱发剂量依赖性类失神性癫痫发作样行为和脑电变化;ECoG特点是双侧皮层同步的"棘─慢波",频率在4.50Hz~6.50Hz(5.50±0.29Hz)之间;在"棘─慢波"放电期间,大鼠停止活动,呈凝视与木僵状态,与经典的致癫痫药物γ─羟基丁酸引起的改变极为相似。本结果表明脑内B型γ─氨基丁酸能递质活动增强可能是失神性癫痫的主要原因。
The influence of GABAB agonist, R-baclofen and gamma hydroxybutyrate on the electrocorticogram and behavior was investigated in the rat. Peripheral injection of baclofen (2 and 4mg/kg) induced a dose-depending absence seizure-like behavior and electrocorticographic changes, characterized by bilateral synchronous spike and wave discharge (SWD)with a frequency from 4. 50 Hz to6. 50 Hz (5. 50±0. 29Hz) . During SWD, the animals became immobile from an alert responsive state. They stared or kept closing eyes.These results were similar to those induced by gamma hydroxybutyrate. Our results demonstrate that GABAB neurotransmission in the brain is involved in the generation of absence seizure.
出处
《锦州医学院学报》
1995年第2期4-7,共4页
Journal of Jinzhou Medical College
关键词
氯苯氨丁酸
失神性
癫痫
γ羟基丁酸
ABAB
baclofen
absence seizures
gamma hydroxybutyrate
rat
electrocorticogram