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氯苯氨丁酸和γ─羟基丁酸诱发大鼠失神性癫痫的比较 被引量:1

COMPARISON BETWEEN ABSENCE SEIZURES INDUCED BY GAMMA HYDROXYBUTYRATE AND BACLOFEN
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摘要 本文观察了γ─氨基丁酸能B受体(GABAB)激动剂氯苯氨丁酸和γ─羟基丁酸对大鼠皮层脑电和行为的影响。腹腔注射氯苯氨丁酸(2和4mg/kg)诱发剂量依赖性类失神性癫痫发作样行为和脑电变化;ECoG特点是双侧皮层同步的"棘─慢波",频率在4.50Hz~6.50Hz(5.50±0.29Hz)之间;在"棘─慢波"放电期间,大鼠停止活动,呈凝视与木僵状态,与经典的致癫痫药物γ─羟基丁酸引起的改变极为相似。本结果表明脑内B型γ─氨基丁酸能递质活动增强可能是失神性癫痫的主要原因。 The influence of GABAB agonist, R-baclofen and gamma hydroxybutyrate on the electrocorticogram and behavior was investigated in the rat. Peripheral injection of baclofen (2 and 4mg/kg) induced a dose-depending absence seizure-like behavior and electrocorticographic changes, characterized by bilateral synchronous spike and wave discharge (SWD)with a frequency from 4. 50 Hz to6. 50 Hz (5. 50±0. 29Hz) . During SWD, the animals became immobile from an alert responsive state. They stared or kept closing eyes.These results were similar to those induced by gamma hydroxybutyrate. Our results demonstrate that GABAB neurotransmission in the brain is involved in the generation of absence seizure.
机构地区 锦州和平医院
出处 《锦州医学院学报》 1995年第2期4-7,共4页 Journal of Jinzhou Medical College
关键词 氯苯氨丁酸 失神性 癫痫 γ羟基丁酸 ABAB baclofen absence seizures gamma hydroxybutyrate rat electrocorticogram
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  • 1高东明,岳春良,常志洁,李鹰,韩晓彬.GABA_B受体活动对大鼠皮层脑电图与行为的影响[J]中国应用生理学杂志,1995(03).

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