奈福泮对豚鼠心肌电生理的影响

Electrophysiological Effects of Nefopam on Isolated Papillary Muscles of Guinea Pigs

奈福泮（Ｎｅｆ）１～１００μｍｏｌ／Ｌ可降低豚鼠心室肌细胞动作电位振幅（ＡＰＡ）和０相上升最大速率Ｖｍａｘ；Ｎｅｆ还可延长复极９０％时动作电位时程（ＡＰＤ_（９０））和有效不应期（ＥＲＰ），同时升高ＥＲＰ／ＡＰＤ_（９０）比值，但使复极２０％时的动作电位时程（ＡＰＤ_（２０））缩短。本实验结果提示：Ｎｅｆ对Ｎａ￣＋、Ｋ￣＋和Ｃａ￣（２＋）的跨膜转运均有抑制作用，与第Ⅰ类抗心律失常药奎尼丁类似。

Nefopam Hydrochloride (Nef) in 1～100 μmol/L could reduce Vmax of phase 0 and APA of the isolated papillary muscle cells of guinea pig; it could prolong the effective refractory period (ERP) and APD_(90), increase the rate of ERP/APD_(90), but could shorten APD_(20).The results suggested that Nef had an inhibitory effect on the transfer of Na￣+.Ca￣(2+). K￣+through cell membrane and was similar to quinidine, class I antiarrhythmic agents.