摘要
应用放射配体结合法检测先天性肾上腺皮质增生13例,先天性阴道闭锁13例,多囊卵巢综合征16例及男性化卵巢肿瘤13例的外周血白细胞雌激素受体(ER)及雄激素受体(AR)。同时应用放射免疫分析检测血浆睾酮(T)及雌二醇(E2)。先天性肾上腺皮质增生患者血E2正常,但ER降低,血T及白细胞AR均增高;先天性阴道闭锁患者血E2及ER均降低;多囊卵巢综合征患者血E2、T及AR均升高;男性化卵巢肿瘤血T、AR均明显升高。以上结果表明血E2和白细胞ER降低及血T和白细胞AR增高,在女性性征异常的发生及发展中起作用。
Specific binding capacity of androgen receptor (AR) and estrogen receptor (ER) on the peripheral leukocytes was detected by radioligand binding assay and plasmal levels of testosterone (T) and estrogen (E2) by RIA in patients with sex differentiation disorders including thirteen congenital adrenal cortical hyperplasia,thirteen congenital atresia vaginalis, sixteen polycystic ovary and thirteen Sertoli-Leydig cell tumor to determine the effect of sex hormones and their receptors on pseudohermaphroditism.The plasma level of E2 was normal and ER lowered, while T level and AR were increased in congenital adrenal cortical hyperlpasia. Both E2 level and ER were decreased in congenital atresia vaginalis. The plasma levels of E2 and T and binding capacity of AR were elevated in polycystic ovary.The T level and AR were markedly increased in Sertoli-Leydig cell tumor. The findings indicate that both the lowered E2 level and ER binding capacity,and the elevated T level and AR binding capacity play a role in the development of female sex differentiation disorders.
出处
《标记免疫分析与临床》
CAS
1995年第4期185-187,190,共4页
Labeled Immunoassays and Clinical Medicine
关键词
性征异常
女性
性激素
受体
Receptors. estrogen
Receptors. androgen
Sex differentiation disorders
Vaginal diseases/abnormality
Adrenal hyperplasia.congenital
Stein-Leventhal syndrome
Sertoli-Leydig cell tumor