奥曲肽对肝硬化病人门脉血流动力学的影响以及与血浆胰高糖素水平的关系

Effects of Octreotide on Portal Hemodynamics in Patients with Liver Cirrhosis and Its Relationship with Glucagon

为探讨奥曲肽减少门脉血流量、降低门脉压和血浆胰高糖素水平的关系，我们研究了肝硬化病人应用奥曲肽前、后门脉血流动力学及血浆胰高糖素水平的变化。静滴奥曲肽后，病人门脉系统血流量及血浆胰高糖素水平均显著下降。奥曲肽可明显减少门脉血流量，因此能有效地用于治疗门脉高压。奥曲肽降低门脉压的机制可能在于抑制胰高糖素的释放。

To investigate the mechanism of action of octreotide on portal hemodynamics and its relationship with plasma Glucagon,we studied the changes of portal hemodynamics and plasma level of glucagcn in cirrhotic patients before and during infusion of octreotide (25μg/h).The blood flow in the portal vein and the plasma level of glucagon were significantly decreased after infusion of octreotide. Octreotide can be used to treat portal hypertension through the reduction of the portal blood flow,which in turn may be induced by the inhibition of glucagon release.