三烯高诺酮和米非司酮对大鼠实验性子宫内膜异位症的治疗作用

Effects of danazol,gestrinone and mifepristone on experimental endometriosis in rats

以手术方法复制大鼠子宫内膜异位症模型，研究三烯高诺酮和米非司酮对实验性子宫内膜异位症的治疗作用。动物随机分为８组：对照组；卵巢摘除组；丹那唑组，２０ｍｇ／ｋｇ；三烯高诺酮组，０．１２５、０．２５、０．５ｍｇ／ｋｇ；米非司酮组，１０、５０ｍｇ／ｋｇ。每天灌胃给药，３周后再次剖腹，取异位子宫内膜称重，并作组织切片，以半自动图象分析仪作子宫内膜形态定量分析，取血清测定雌二醇（Ｅ２）、孕酮（Ｐ）浓度。结果表明，三烯高诺酮和米非司酮均能抑制异位子宫内膜的生长，且表现为剂量依赖性。三烯高诺酮能使鼠血清Ｅ２、Ｐ水平降低，米非司酮对鼠血清Ｅ２水平无明显影响，但使Ｐ水平升高。

bjectives:To investigate the therapeutic effect of gastrinone and mifepristone on experimental en-dometriosis in rats. Design:Experimental studies in rats. Settings:Laboratory in the Center of Reproductive Medicine Tongji Medical University.Metbods:Mature female S. D. rats with experimental endometriosis induced by surgical operation were divided into 8 groups; control;castrated;danazol 20 mg/kg;gestrinone 0.125,0.25,0.5 mg/kg;mifepristone 10,50mg/kg.After daily oral administration for 3 weeks,the rats were laparotomized again,the ectopic en-dometriall implants were weighed their morphologic features were analysed quantitatively by semi-automatic image analysis system,the serum estradiol and progesterone concentrations were determined with RIA. Results:Atrophy of ectopic endometrial implants was shown in all experimental groups,except in groups treated with 0.12 5 mg/kg gestrinone or 10mg/kg mifepristone.Serum estradiol and progesterone concentrations decreased singificantly in the 0.25,0.5mg/kg gestri none treated-groups. Serum proges-terone concentration increased considerably in the 50 mg/kg mifepristone treated-group.Conculsion:Gestrinone(0.25,0.5mg/kg)and mifepristone(50 mg/kg)presented an inhibitory effect on ectopic endometrial implants in rats with experimental endometriosis.