通里攻下法与活血化瘀法治疗犬急性出血坏死性胰腺炎机理研究─—抗氧化及对RCIA的影响

Study on the Mechanism of Treatment of Canine Acute Pancreatitis with the TheraputicMethods of Purgating and Activating of BloOd Circulation to Dispersing Blood Stasis : Astioxi-dation and Influence on RCIA

通里攻下与活血化瘀是中西医结合治疗急腹症的两个重要治法。本文采用牛磺胆酸钠致犬急性出血坏死性胰腺炎（ＡＨＮＰ）模型，研究了ＡＨＮＰ氧化／抗氧化平衡及红细胞免疫功能（ＲＣｌＡ）。通里攻下与活血化瘀的代表方药—大承气汤及丹参的抗氧化作用及其对ＲＣＩＡ的影响。本文提示：①牛磺胆酸钠致ＡＨＮＰ存在氧化／抗氧化平衡失调，活血化瘀及通里攻下均具有抗氧化作用；②通里攻下后动物胰重及腹水量明显减少；③本文首次发现ＡＨＮＰ的红细胞免疫功能损害，通里攻下能明显提高ＲＣＩＡ。

erbal purgation and activating blood circulation and dispersing blood stasis are two majortherapeutic methods of integrated traditional Chinese with westerm medicine in the managementof acute abdominal dlseases. Oxidation/antioxidation balance,red-cell(erythrocyte) immuneadherence (RCIA)in a model of experimental pancreatitis induced by sedium taurocholate wereinvestigated. Decoction for potent purgation(Da Clienqi Tang)and injectio Salvia Miltiorrhizaewere used as representative prescriptions of the two theraputic methods。Results showed: 1.Oxi-dation/antioxidation imbalancce involved in canine acute hemorrhagic necrotizing pancreatitis in-duced by sodium taurocholate。 Both drugs could be served as antioxidants。2. The weight of thepancreas and volume of peritoneal flu]d were reduced after purgatlon treatment.3.ImpairedRCIA function was revealed, and effect related to lipid peroxidation。 Herbal purgation resumedRCIA significantly。