家兔肝叶切除手术前后的血液流变学对比观察

Compared Observation of Blood Rheology for Rabbits befor and ofter Lobectomy of Liver

本文通过对２４只北京大耳兔，左肝叶切除手术前后的血液流变学对比观察，结果显示家兔术后有明显的血液流变学变化：血细胞压积下降非常显著，Ｐ＜０．００１。而全血粘度随剪切率的升高，比术前下降的幅度逐渐缩小，３．６￣（ｓ－１）时Ｐ＜０．０１，３６￣（ｓ－１）时Ｐ＜０．０５，到２１０￣（ｓ－１）时则无明显差异，Ｐ＞０．０５，这说明红细胞的刚性有显著增强；血小板聚集，纤维蛋白原、血浆粘度及血沉在术后均极显著升高，Ｐ值均＜０．００１。实验结果提示：家兔在手术后这种血液流变性质的异常及高凝现象的存在，直接印证了临床外科术后多现血瘀证的观察结论，并为临床外科术后采用活血化瘀辨证治则提供了实验研究依据。

hrough the investigation of blood rheologic change before and after left lobectomy of liver,Beijing big ear rabbites with blood stasis were confirmed after the operation. The packed cell volume has decreased greatly(P<0.001).While the blood viscosity de-creased,lobectomy of liver resulted in less decreasing of blood viscosity(P<0.01 when 3.6￣(s-1);P<0.05,when 36￣ (s-1)Vs. P> 0.05when 210￣(s-1)).It showed remarkable reinforeement of RBCrigidity. The value of aggregation of platelet,fibroingen,plasm viscosity and blood sedimentation in-creased obviously after the operation(P<0.00 1).The findings of blood rheological abnormalityand higher coagulation of the rabbits following the left lobectomy of liver account for the bloodstasis of the patients after surgical operation.Those also provide reference standards for diagnosisof blood stasis after clinical operation.