摘要
用过氧化物酶与抗过氧化物酶（ＰＡＰ）法检测了７３例肝细胞癌（ＨＣＣ）患者肝组织中的丙型肝炎病毒抗原（ＨＣＶＡｇ）和ＨＢｓＡｇ及ＨＢｃＡｇ。结果显示，ＨＣＶＡｇ、ＨＢｓＡｇ和ＨＢｃＡｇ的检出率分别为２８．８％、７５．３％和２６．０％；ＨＣＶＡｇ阳性的肝细胞多呈散在型分布，ＨＣＶ染色颗粒既可见于细胞浆也可见于细胞核；ＨＣＶＡｇ的检出与ＨＢＶ的感染状态无显著相关。提示，ＨＣＶ可在ＨＣＣ患者的肝细胞中表达，ＨＣＶ感染可能在我国ＨＣＣ的发生中起一定的病原学作用。
Liver
samples from 73 patients with hepatocellular carcinoma(HCC)were
detected for hepatitis C virus antigen (HCVAg) HBsAgand HBcAgby
peroxidase-antiperoxidase(PAP)method The positive rates of HCVAg
HBsAgand HBcAgwere 28. 8% 75.3%and 26.0%respectively HCVAgpositive
hepatocytes were distributed sporadically,and HCVAggranules were
found in cytoplasm and nuclei of the hepatocytes No correlation was
found between HCVAgand HBV infectious status。 These results
suggested that HCV infection may play an etiological role in the
development of HCC in China。
关键词
肝细胞癌
丙型肝炎病毒
抗原
定位
Hepatocellar carcinoma Hepatitis
C virus Antigen Peroxidase
