摘要
我们研究发现在传代培养的大鼠贮脂细胞中，不同浓度的血管活性肠肽（Ｖａｓｏａｃｆｉｖｅｉｎｆｅｓｆｉｎａｌｐｅｐｔｉｄｅ，ＶＩＰ）能显著抑制Ⅰ型胶原分泌并呈量效关系。ＶＩＰ受体拮抗剂能减弱ＶＩＰ这一作用，从而更加肯定ＶＩＰ抑制胶原分泌的作用。本研究提示：大鼠贮脂细胞膜上存在ＶＩＰ受体；ＶＩＰ在肝纤维化和肝硬化时浓度升高可能调节肝脏胶原代谢。
Lipocytes(Ito cells)are primary cellular source of hepatic collagen.
Some reports demonstrated that high plasma levels of vasoactive
intestinal peptide(VIP)was detected in patients with cirrhosis or in
animal models of cirrhosis.To investigate whether VIP involving in
secretion of collagen by lipocytes or not,we observed that the
effects of VIP at various concentrations on the secretion of collagen
type I by rat Ito cells in vitro. The data showed that VIP obviously
inhibited the secretion of collagen in a dose-dependent
manner(r=0.989,n=6,P<0.001).VIP receptor antagonist declined the
inhibitory action of VIP on secretion of collagen.These results
suggest that:the existence of VIP receptors on plasma membrance of
rat lipocytes ;VIP may regulate the metabolism of collagen in liver
fibrosis or cirrhosis by its high plasma level.
出处
《肝脏病杂志》
CSCD
1995年第3期144-146,共3页
关键词
胶原
血管活性肠肽
肝纤维化
贮脂细胞
受体
Collagen
Vasoactive intestinal peptide Liver fibrosis Lipocyte Receptor
