摘要
本研究测定1994年南京市热浪袭击期间20例重症中暑患者及12例正常人血浆β-内啡肽浓度变化并对纳洛酮治疗中暑患者的临床效果进行评价。全部中暑病例随机分为纳洛酮治疗组和对照组，每组各10例。各级病例均立即抽取静脉血2ml，纳洛酮治疗组每次静注纳洛酮1．2mg，每次间隔30分钟，共三次，并于每次注药后5分钟各抽取静脉血2ml。纳洛酮治疗组和对照组即刻血浆β-内啡肽含量（各为82．40±16．16ng／L与71．54±11．41ng／L）均较正常人组（31．08±4．86ng／L）显著升高（P＜0．01）；治疗组血浆β-内啡肽含量变化明显地表现为下降趋势，尤以即刻与第二次纳洛酮注射后值（37．00±7．61ng／L）、即刻与第三次用药后值（31．57±7．53ng／L）间差异显著（P＜0．01）；对照组各时间点β-内啡肽值无显著差异（P＞0．05）。第三次注射纳洛酮后，治疗组的收缩压增值及体温、神志、头痛缓解时间与对照组相比，均有显著性差异（P＜0．01）。上述结果提示，纳洛酮可望作为重症中暑抢救的治疗药物之一。
The plasma β-Endorphine (β-EP) concentration of 20 cases of severe heatstroke and 12 normal persons were measured, the changes of β-EP level after naloxone treated in 10 cases of the 20 patients were observated. These 20 patients were randomly dividedinto two groups: naloxone treating group and routine treating group. Naloxone (1. 2mg)was injected intravenous every 30 nimutes for three times and blood samples were taken perior to the first injected and 5 min after every naloxone injected (that is, 0min, 5min, 35min,and 65min). The other one received routine treat only as control, and blood samples weretaken respectively as naloxone treating group. The results showed that: (1)β-EP level is31. 08±4.86ng/L in the mormal person, 82. 40±16. 16ng/L in naloxone treating group before treatment and 21. 54±11. 41ng/L in the control group. there are significantly differencecompare with the normal person (P<0. 01), but no difference between two therapy groups(P>0. 05); (2)following naloxone administered, especially at 35min and 65min, β-EP levelwere more reduced than that prior to injection (P<0. 01); (3)The elevations of systolic bloodpressure in naloxone treating group were more than that of control (P<0.05); (4)CourseThe and average days of stay in hospital of naloxone treating group is also less than that ofcontrol (P<0. 01). The results indicatcd that heat stress is an important factor to stimulatethe secretion and release of β-EP and naloxone might be a effective agent for cure heatstroke.
出处
《急诊医学》
CSCD
1995年第2期79-83,共5页
