P^（53）蛋白和PCNA在肺癌中的表达与预后的关系

Expressions of P￣(53) protein and proliferating cell nuclear antigen in lung cancer and their relationships with prognosis

应用ＬＳＡＢ免疫组化方法检测了８２例原发性肺癌组织标本Ｐ^（５３）蛋白及增殖细胞核抗原（ＰＣＮＡ）的表达．结果显示肺癌Ｐ^（５３）蛋白表达与ＰＣＮＡ表达间呈显著正相关（Ｐ＜０．０１），Ｐ^（５３）蛋白阳性表达者ＰＣＮＡ分级显著高于Ｐ^（５３）蛋白阴性表达者；Ｐ^（５３）蛋白及ＰＣＮＡ的表达均与肺癌组织学分级关系不显著（Ｐ＞０．０５）．在肺腺癌有无淋巴结转移两组间Ｐ^（５３）蛋白及ＰＣＮＡ表达均有显著性差异且与患者的预后有关（Ｐ＜０．０５），提示两者的检测对于评估肺腺癌患者的预后有重要意义；在肺鳞癌，ＰＣＮＡ表达与患者的预后有关（Ｐ＜０．０５），而Ｐ^（５３）蛋白表达与患者预后的关系不显著（Ｐ＞０．０５）．

The expressions of P￣(53) protein (P￣53) and proliferating cell nuclear antigen (PCNA) were examined by immunohistochemical techniques in 82 cases with primary lung cancer. The results showed that there was significant correlation between the expression of P￣(53) and that of PCNA (P<0. 01 ) , the PCNA semiquantitative grade of P￣(53) positive cases was significantly higher than that of P￣(53) negative cases, and the expressions of P￣(53) and PCNA were not correlated with the histological grade (P>0. 05) In pulmonary adenocarcinoma, the expressions of P￣(53) and PCNA were correlated with lymph node metastasis and the prognosis of patients (P<0. 05), suggesting that the detection of P￣(53) and PCNA be of great significance in the evaluation of prognosis. In squamous cell carcinoma, the expression of PCNA was correlated with the prognosis of patient (P<0. 05), but the expression of P￣(53) was not (P>0. 05 ).