摘要
应用LSAB免疫组化方法检测了82例原发性肺癌组织标本P^(53)蛋白及增殖细胞核抗原(PCNA)的表达.结果显示肺癌P^(53)蛋白表达与PCNA表达间呈显著正相关(P<0.01),P^(53)蛋白阳性表达者PCNA分级显著高于P^(53)蛋白阴性表达者;P^(53)蛋白及PCNA的表达均与肺癌组织学分级关系不显著(P>0.05).在肺腺癌有无淋巴结转移两组间P^(53)蛋白及PCNA表达均有显著性差异且与患者的预后有关(P<0.05),提示两者的检测对于评估肺腺癌患者的预后有重要意义;在肺鳞癌,PCNA表达与患者的预后有关(P<0.05),而P^(53)蛋白表达与患者预后的关系不显著(P>0.05).
The expressions of P ̄(53) protein (P ̄53) and proliferating cell nuclear antigen (PCNA) were examined by immunohistochemical techniques in 82 cases with primary lung cancer. The results showed that there was significant correlation between the expression of P ̄(53) and that of PCNA (P<0. 01 ) , the PCNA semiquantitative grade of P ̄(53) positive cases was significantly higher than that of P ̄(53) negative cases, and the expressions of P ̄(53) and PCNA were not correlated with the histological grade (P>0. 05) In pulmonary adenocarcinoma, the expressions of P ̄(53) and PCNA were correlated with lymph node metastasis and the prognosis of patients (P<0. 05), suggesting that the detection of P ̄(53) and PCNA be of great significance in the evaluation of prognosis. In squamous cell carcinoma, the expression of PCNA was correlated with the prognosis of patient (P<0. 05), but the expression of P ̄(53) was not (P>0. 05 ).
出处
《诊断病理学杂志》
CSCD
1995年第4期221-223,共3页
Chinese Journal of Diagnostic Pathology
关键词
肺肿瘤
P53蛋白
增殖细胞核抗原
预后
Pulmonary neoplasms P ̄(53) protein Proliferating cell nuclear antigen Prognosis