鼻咽癌雌孕激素受体的研究

A study on estrogen and progesterone receptors in nasopharyngeal carcinoma

应用免疫组化ＳＰ法，观察了５７例鼻咽癌组织中的ＥＲ、ＰＲ表达情况。ＥＲ和ＰＲ的阳性率分别为４５．６１％（２６／５７）和４９．１２％（２８／５７）。临床分期及ＶｃＡ－ＩｇＡ滴度与ＥＲ、ＰＲ阳性率呈反相关性。结果亦表明：联合检测ＥＲ、ＰＲ及ＶｃＡ－ＩｇＡ滴度，可提高判断鼻咽癌预后的准确性，作者认为鼻咽癌应属于ＥＲ、ＰＲ高表达肿瘤，可考虑采用内分泌治疗。

This is a study on estrogen and progesterone receptors in nasopharyngeal carcinoma (NPC) examined by.S-P immunohistochemical method,similar report not having been known previously.57 cases with NPC were diagnosed pathologically.The results showed:① The postive rate of estrogen receptors (ER) was 26/57 (45.61%) and that of progesterone receptors (PR),28/57 (49.12%).② In stage IV patients,when both ER and PR were negative, the rate of accordance of the findings with the stage was 31.6%;when ER and PR were negative and VCA-IgA was 1:40,the rate was 9/12 (75%);and when only VCA-IgA was assayed and its height was 1:40,the rate was 13/33 (39.4%).③ The total rate of complete cure (CR) was 38/49 (77.6%). In summary,we regard that NPC is a tumor with high expression of estrogen and progesterone receptors,the positive expression can reflect the clinical occurrence and progression of the tumor and is related to the short-term therapeutic effects.It is suggested to use endocrine therapy for treatment of NPC.