异基因骨髓移植后GVHD的皮肤病损组织学特点

Histological features of skin of graft-versus-host disease following allogeneic bone marrow transplantation

本文介绍异基因骨髓移植后，移植物抗宿主病（ＧＶＨＤ）的皮肤病损组织学特点。通过病例的活检和尸检的皮肤病变，指出ＧＶＨＤ是以皮肤病损为特征，而且皮肤的症状出现最早，故皮肤活检确诊ＧＶＨＤ是十分重要的。认为表皮内出现木乃伊小体、淋巴细胞浸润及基底细胞变性、液化坏死，这三点是诊断ＧＶＨＤ皮肤病损的主要病理形态依据。同时，本文根据皮损特点提出有关ＧＶＨＤ诊断的注意点。

The histological features of skin lesion of graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation were described. By biopsy and autopsy examinations of a case with GVHD, it is indicated that the skin is one of the main targets of the disease. Because of the early appearance of skin symptoms and signs, taking skin biopsy has great significance in early diagnosis of the disease. It is considered that epidermal infiltration of lymphocytes, the formation of mummified bodies, and basal cell degeneration, liquefaction and necrosis are the three main pathological diagnostic criteria of the disease. According to the features of the skin lesion,the attention points in diagnosing GVHD were discussed. The survival time was long in this case and there were biopsy, autopsy and immunohistochemical examination materials, that are rare in our country.