脑转移性肿瘤的原发灶来源探讨

Identification of the Primary Sites of Metastatic Brain Tumors——Immunohistochemical Study

用13种原发肿瘤的特异标志抗体,对147例脑转移性肿瘤进行标记,免疫组化技术(ABC法)测试结果显示:大多数脑转移性肿瘤来源于肺癌。来源于胃、肠的癌肿比乳癌、甲状腺癌和绒癌要多。这些抗体的总阳性率在88％以上。免疫组化法在寻找脑转移性肿瘤的原发灶、原发性和继发性脑瘤的鉴别诊断中,都是很有价值的。

A hundred and forty seven specimens of metastatic brain tumors were labeled with thirteen antibodies which are specific markers to various primary cancers. The results of the im-munohistochemical technique (ABC method) showed that most primary sites of the metastatic brain tumors can be found by these methods. Most, of the brain metastases originated from the lung carcinomas and more originated from the stomach and colon carcinomas than (rom the breast, thyroid, and choriocarcinomas. The positive rates of all these antibodies were over 88%. These methods may be much more valuable in differentiating diagnosis between primary and secondary brain tumors and in metastases of other organs detecting the unknown primary sites.