摘要
发现人红白血病细胞株ＴＦ－１可在人重组白细胞介素－９（ＩＬ－９）刺激下长期生长达５个月，ＩＬＬ－９可抑制ＴＦ－１细胞的ＤＮＡ片段化，抗ＧＭ－ＣＳＦ抗体可抑制ＩＬ－９刺激的ＴＦ－１细胞增殖，从而提供了ＩＬ－９的一个新生物学效应。
we found a human erythroleukemia cell
line TF-1 could be stimulated by recombinant human interleukin-9
(IL-9)to long term proliferation up to 5 months, and cellular DNA
fragrnentation was inhibited.The antibody a-gainst human
granulocyte-macrophage colony stimulating factor(GM-CSF)inhibited the
effect of IL-9. This studysuggests that IL-9may induce an autocrine
loop of growth in the TF-1 cells. The results here provide a new
bio-logical effect of IL-9.
出处
《北京医科大学学报》
CSCD
1995年第5期323-325,I027,共4页
Journal of Peking University(Health Sciences)
基金
美国洛氏基金
关键词
白血病
白细胞介素-9
免疫药理学
Headings
Interleukin-9/pharmacol
Tumor cells,cultured/drug eff
Leukemia
