新疆宫颈癌与人乳头瘤病毒(HPV)感染关系的初步研究

A Preliminary Study of the Relationship between Human Papillomaviruses(HPV)Infection and Uterine Cervical Carcinoma(UCC)in Xinjiang

本文用核酸杂交法对以维吾尔族为主的宫颈癌及非癌宫颈组织进行了HPV-DNA相关序列的检查。标本有宫颈癌33例、宫颈糜烂1例和正常宫颈1例。在33例宫颈癌中维吾尔旅有25例,其余8例包括汉、蒙古、回和柯尔克孜等四个民族。结果是在维吾尔族病例宫颈癌组织中HPV-DNA相关序列检出率达80％,以HPV_16型为主,核酸多呈整合状态存在。上述结果表明,HPV在新疆某些地区内的人群中感染及传播的情况可能比较普遍。但要进一步阐明HPV与宫颈癌的病因学关系,尚需做更多的工作。

This article reported a preliminary result about the HPV-DNA homolo gous sequences in biopsy specimens from 33 cases of squamous cell carcinoma of the uterine cervix, one of cervical erosin and one sample of normal uterine cervix tissue by Southern blot hybridization with two HPV probes. In the 33 cases of the cervical cancer, 25 came from Uygur, the rest from Han, Mongol, Hui and Khalkhas severally. The results showed that the cases of Uygur, the positive hybridization for the HPV probe in(UCC) is 80%, and most types of those are HPV 16. Their nucleic acid are conformable. It is probable that the HPV infection and propagation is widespread in some minority people in Xinjiang. However some more investigation need to be done for expounding the relationship of the etiology between HPV and cervical cancer.