米非司酮终止早孕流产物的病理观察

The pathological investigations on termination of early pregnancy with mifepristone

对米非司酮（ＲＵ４８６）联合米索前列醇抗早孕的流产物１３３例进行大体检查、镜下检查和超微结构的研究，并以同期停经４９日内人工流产标本１３３例作为对照组，比较流产物形态学的变化。结果显示，不同剂量药物流产者的流产物病理变化差异无显著性，而药物流产者绒毛退化的量及其退变程度均远较对照组严重。本文还讨论了ＲＵ４８６对蜕膜及绒毛的影响，提出ＲＵ４８６是否直接作用于滋养细胞的问题值得进一步研究。

33 samples of induced early abortions using mifepristone(RU486)in combination with misoprostol(Miso)were examined.There were no significant difference in the outcome and pathological changes between the two groups with varied RU486-Miso dosages. Another 133 samples of abortus(gestational age≤49 days)from vaccum aspiration were used as control.The villi of RU486-Miso group showed more extensive and severer degeneration than the villi of the control group under light and electron mi-croscopy。However,whether RU 4 8 6 affects the trophoblasts directly or in directly is yet in dispute.Further investigation is needed.