摘要
对１０６例不同疾病新生儿和４０例正常新生儿用萘酚ＡＳ—ＭＸ法测定白细胞硷性磷酸酶活性（ＬＡＰＡ）。结果：①细菌感染组治疗前ＬＡＰＡ明显高于对照组、非感染组和病毒组（Ｐ均＜０．０１）；病毒感染组ＬＡＰＡ明显低于对照组（Ｐ＜０．０５）。②细菌感染组治疗后ＬＡＰＡ下降，与治疗前比较有非常显著性差异（Ｐ＜０．０１）；病毒感染组治疗后ＬＡＰＡ增高，明显高于治疗前（Ｐ＜０．０１）；非感染组治疗前后无差异（Ｐ＞０．０５）。③１０例严重细菌感染的濒死患儿入院时ＬＡＰＡ明显低于一般感染组和对照组（Ｐ均＜０．０１），治疗后明显高于治疗前（Ｐ＜０．０５）。提示ＬＡＰＡ不但是诊断新生儿感染性疾病有意义的检测指标，而且对细菌和病毒性疾病的鉴别及判断疗效和估计预后有重要的临床价值。
Leukocyte alkaline phosphatase activity (LAPA) was examined in 106 cases with neonatal diseases and 40 normal neonates (control). The results showed that ① LAPA was statistically elevated in bacterial infectious group than that in viral infectious group,noninfectious group and control. It decreased after cure as compared with pretreatment(p< 0. 01); ② LAPA was significantly lower in viral infectious group than that in control (P< 0. 05). It increased after cure as compared with pretreatment (P<0.01); ③ In agonal cases with bacterial infection, LAPA was significant lower than that in control (P<0.01), when the patients recovered, LAPA increased as compared with pretreatment (P<0. 05). The results indicate that LAPA is an important indicator in neonatal bacterial infection and can be used to distinguish bacterial from viral infection, and may be helpful to assess the prognosis.
关键词
新生儿疾病
诊断
白细胞
碱性磷酸酶
leukocyte alkaline phosphatase activity
neonate diseases
diagnosis
