激光血管成形术后再狭窄与平滑肌细胞增殖

THE PROLIFERATION OF SMOOTH MUSCLE CELLS AND RESTENOSIS AFTER LASER ANGIOPLASTY

为探讨激光血管成形术后再狭窄的机理，将新西兰兔随机分为正常对照（Ｎ）组、动脉粥样硬化（ＡＳ）组和激光血管成形术（ＬＡ）组。首先建立ＡＳ模型和ＬＡ，术后不同时间取腹主动脉做组织形态学、细胞生物学检查。结果发现，ＬＡ后再狭窄与血管热损伤后动脉中层平滑肌细胞（ＳＭＣ）向内膜下迁移并异常增生有关，导致新生内膜形成、内膜增厚和血管再狭窄发生。

The Purpose of this study was to make clear the mechanism of restenosis after laser angioplasty(LA).The New Zealand rabbits fell into normal control group,atherosclerotic group and LA group.The rabbit abdominal aorta atherosclerotic and LA models were et up and then the sections of lesion artery were taken for histo-mor-phological and cellular biological study.The results showed that restenosis after LA was associated with the mi-gration of medium SMC to intima and excessive proliferation of SMC.