肝炎灵对慢性乙型肝炎患者血清病毒标志的影响

Effect of Gan-Yan-Ling in serum HBVM of patients with chronic viral hepatitis B

为观察肝炎灵对慢性肝炎病人血清乙型肝炎病毒标志的影响。治疗组(34例)用肝炎灵,对照组(35例)用聚肌胞。该药对HBsAg阴转率为9％,抗-HBc为3％,疗效不显(P均>0.05);对HBeAg的阴转率为74％,疗效明显(P<0.005),经6mo-1yr随访,远期疗效为65％;对抗-HBe的阳转率为32％。说明肝炎灵对抑制乙肝病毒复制,使HBeAg转阴较聚肌胞为优,远期疗效较持久。该药价格低廉、毒副作用小,值得扩大临床使用和研究。

In order to study the effect of Gan-Yan-Lihg in serum HBVM of patients with chronic viral hepatitis B,we divided the patients into two groups. Group I , 34 patients on Gan-Yan-Ling, 2 ml bid im, and group Ⅱ , 35 patients on poly I-C, 2 ml qd im, as the control. After the treatment of 3 mo, the negative conversion rate of HBeAg was 74% in group I , and 26% in group Ⅱ . The positive coflversion rate of Anti-HBe in group I was 32% with a follow up period of 0.5-1 yr.This result showed that Gan-Yan-Ling was more effective in treating viral hepatitis B than Poly I-C.Owing to its safety and cheapness, it is suitable for clinical application.