3Humbert M, Sitbon O, Simonneau G. Drug therapy : Treatment of pulmonary arterial hypertension [ J]. N Engl J Med, 2004,351 (3):1 425-1436.
4Blumberg FC, Guter AJ. Hemodynamic effects of aerosolized iloprostin pulmonary hypertensionat rest and during exercise [ J ]. Chest ,2002,121 ( 5 ) : 1 566 - 1 571.
5CF Opitz, R. Wensel M. Bettmann, et al. Assessment of the vasodilator response in primary pulmonary hypertension. Compare prostacyclin and iloprost administered by either infusion or inhalation [ J ]. European Heart Journal,2003,24 (4) :356 - 365.
6Christman BW, MePherson CD, Newman JH, et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension [ J ]. N Engl J Med, 1992,327 ( 2 ) : 70 - 75.
7Tuder RM, Cool CD, Geraci MW, et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension [ J ]. Am J Respir Crit Care Med, 1999,159 (6) :1 925 -1 932.
8Hoshikawa Y, Voelkel NF, Gesell TL, et al. Prostacyclin receptor- dependent modulation of pulmonary vascular remodeling[ J]. Am J Respir Crit Care Med,2001,164( 2 ) :314 - 318.
9Moncada S, Gryglewski R, Bunting S, et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation [ J ]. Nature, 1976,263 (5 579) :663 -665.
10Hoshikawa Y,Voelkel NF, Gesell TL, et al.Prostacyclin recep- tor-dependent modulation of pulmonary vascular remodeling [J].Am J Respir Crit Care Med,2001,164(3):314-318.