摘要
L—四氢巴马汀(L—THP),L—千金藤立定(L—SPD)10mg/kg,iv,和四氢小蘖碱(THB)3mg/kg,iv,均能增加心肌血流量,分别为99,72,231％,降低冠脉阻力(各为48,63,68％),降低心肌耗氧量(分别为38,31,23％)。三药均可降低血压,持续1小时以上。心率略减慢,但不显著。
Experiments on anesthetized dogs showed that 1-tetrahydropalmatine (1-THP, 10 mg/kg, iv ) , 1-stepholidine ( 1-SPD, 10 mg/kg, iv ) and letrahy-droberberine ( THE, 3 mg/kg, iv ) increased myocardial blood f low ( by 99, 72 and 231% respectively ) and decieased coronary resistance ( 48, G3, 68% ) and cardiac oxygen consumption (38, 31, 23% ). They also caused drop of blood pressure for more than 1 hour. The heart rate was slightly slowed by these drugs, but the change was not significant.
出处
《徐州医学院学报》
CAS
1989年第2期79-82,共4页
Acta Academiae Medicinae Xuzhou
关键词
四氢巴马汀
心肌耗氧量
血压
1-tctrahydropalmatine
1-stepholidine
tetrahydroberberine
myocardial blood flow
cardiac oxygen consumption
blood pressure
heart rate
