摘要
于22只清醒、肌松、切断双侧迷走神经家兔,记录膈神经放电,观察小脑延髓池注射不同剂量的东莨菪碱对其影响。东莨菪碱0.1mg/kg无明显作用。0.5和5.0mg/kg可使膈神经放电脉冲计数减少,幅度变小。结果提示东莨菪碱对呼吸中枢产生抑制效应。
In 24 conscious, vagotomized, curarized and artificially ventilated rabbits the efferent phrenic discharge was recorded. Scopolamine 0.1, 0.5 and 5.0 mg/kg was injected into the cerebello-medullary cistern. The effect of scop-olamine 0.1 mg/kg on respiration was insignificant, but the frequency and amplitude of phrenic discnarge were decreased by increasing scopolamina to 0.5 or 5.0 mg/kg. These results indicate that scopolamine inhibited respiratory centers in the rabbit.
出处
《徐州医学院学报》
CAS
1989年第2期95-97,共3页
Acta Academiae Medicinae Xuzhou
关键词
东莨菪碱
膈神经放电
scopolamine
phrenic discharge
cerebcllo-medullary cistern
rabbits
