家畜的消化系统增生性病变与癌前病变的研究

STUDY ON THE HYPERPLASTIC AND PRECANCEROUS LESIONS OF THE DIGESTIVE SYSTEM IN DOMESTIC ANIMALS

增生性病变与癌前病变的研究对于肿瘤的早期诊断、早期防治以及认识肿瘤在形态学上的发生发展过程均有重要意义。国内外医学对这一方面的研究日益重视,但在兽医科学领域中,尚未引起注意。本文作者应用病理组织学方法,对家畜和一部分野生动物的食管、胃和大小肠等消化系统组织共1,037例进行了研究,检出了一批增生性病变和癌前病变,它们是:上皮的单纯性增生、上皮的乳头状增生、粘膜白斑、慢性溃疡、上皮的不典型增生、乳头状瘤和腺瘤性息肉。研究中并发现上皮的异型性增生、乳头状瘤癌变为原位癌与浸润癌,以及腺瘤性息肉恶变为腺癌等移行现象。 本文重点描述检出的各种增生性病变与癌前病变的形态学特征,并对某些病变向癌转变的移行现象进行了分析讨论。

Numerous hyperplastic and precancerous lesions of the digestive system were observed in 1,037 different tissues of animals ( including 882 esophagi, 124 stornaches and 91 intestines ) . The esophageal lesions were as follows: Simple hyperplasia of eso-phageal epithelium ( 32 cases, 3.89%), esophageal mucosal leukasmus ( 3 cases, 0.36%), atypical hyperplasia of esophageal epithelium( 5 cases, 0.6% ) , and a carcinoma in situ that results from atypical hyperplasia of esophageal epithelium. The gastric lesions included simple hyperplasia and atypical hyperplasia of the gastri epithelium (7 cases, 5.64% and 16 cases, 12.9% respectively), mucosal leukasmus ( 2 cases, 1.61%), chronic ulcers ( 8 cases, 6.45%), papillomas ( 4 cases, 3.22%), adenomas ( 3 cases, 2.41 %) and 8 cases of gastric squamous cell carcinomas which developed from atypical hyperplasia of gastric epithelium and papillomas. Some tumour lesions such as adenomatoid polyps ( 4 cases, 4.39%) were observed in the intestines. One case of adenocarcinoma was detected from a colonic adenomatoid polyp with malignant changes and may be an important subject for research in cancerology of animals.