有机稀土化合物对SOS反应的抑制作用①

SUPPRESSIVE EFFECTS OF ORGANIC RARE EARTH COM-POUNDS ON INDUCED SOS RESPONSES

本文应用ＳＯＳ显色法研究了三种有机稀土化合物及其相应鳌合剂的抗诱变作用。抗坏血酸稀土、柠檬酸稀土及乙二胺四乙酸稀土浓度分别在０．５～２．５ｍｇ／ｍｌ、１～２Ｏｍｇ／ｍｌ及５～４Ｏｍｇ／ｍｌ时，对已知致癌物亚硝基胍和３，４—苯并芘诱导的ＳＯＳ反应具有抑制作用，且有较好的剂量效应关系。而单纯的螫合剂抗坏血酸抗诱变效果很好，柠檬酸显示微弱的抗诱变性，乙二胺四乙酸二钠则无抗诱变作用。

The author investigated antimutagenicity of organic rare earth compounds andtheir chelate agents by SOS chromotest.The rare earth ascorbate(RE AS),rare earth cit-rate(RE Cit) and rare earth EDTA(RE EDTA)at the concentrations of 0.5 2.5mg/ml,1 20mg/ml and 5 40mg/ml suppressed the SOS responses induced by MNNG or B(a)P,which are known as mutagens,with dose effect relations. The chelating agents of the or-ganic rare earth compounds showed the different effects. ASA showed a high antimutageniticactivity. Cit inhibited slightly SOS function.Na2 EDTA had no antimutagenicity.