摘要
采用生物学检测技术，对广西某肝癌高发区的８３份饮用水进行了诱变性评价，并分别对四组饮用塘水和非塘水的１２９名成年男性居民和２１３名儿童进行了细胞遗传毒性损伤的分析。结果：各类饮用水的诱变性阳检率为４５．７８％，其中，塘水的阳检率高达９３．３３％（２８／３０），而深井水全部为阴性（０／９）。塘水中存在的化学诱变物质对紫露草花粉母细胞和鱼周血红细胞均具有潜在的遗传毒性。从幼年即已开始饮用塘水的儿童和成年男性居民，周血淋巴细胞的微核率、核碎裂率、姐妹染色单体互换率和染色体畸变率等遗传毒理学指标均与饮用非塘水的对照组居民有显著差异。本文的研究结果为进一步确证饮水污染与肝癌的病因学关系提供了生物学证据。
Abstract THE mutagenicity of 83 samples of drinking water
and cytogenotoxic effects in theinhibitants(129 adults and 213 children) drinking pond water in
an area prevailing with livercancer were examined. The results showed that the rates of
positive response to the muta-genicity tests vvith pollen mother cells of Tradescantia were:93.
3%(28/30)to the pond wa-ter,0%(0/9)to the deep well water,and the overall average rate was 45.
8%. The chemicalmutagens in the pond water had potential cytogenotoxicity to pollen mother
cells of Trades-&&
出处
《癌变．畸变．突变》
CAS
CSCD
1995年第5期306-310,共5页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
卫生部资助
