HBV感染对原发性肝癌患者血清AFP值的影响

THE INFLUENCE OF SERUM AFP LEVEL ON HBV INFECTIONS PATIENTS WITH PRIMARY HEPATOCELLULAR CANCER

本文报道测定１０８例ＰＨＣ者的血清ＡＦＰ值和ＨＢＶ感染标记。７１例（６８．５％）ＡＦＰ值＞２０μｇ／Ｌ，其中６５例ＡＦＰ值＞ １００μｇ／Ｌ；ＨＢｓＡｇ阳性者９６例（８８．９％），ＨＢｓＡｇ阴性者１２例（１１．１％），ＨＢｓＡｇ阳性者ＡＦＰ值的中位数为５０５ μｇ／Ｌ（２０～２２３４μｇ／Ｌ）显著高于ＨＢｓＡｇ阴性者的２０μｇ／Ｌ（２０－３８３μｇ／Ｌ）。ＨＢｓＡｇ阳性者ＡＦＰ值升高的峰值年龄组与ＰＨＣ发病的年龄高峰相吻合。ＡＦＰ值呈随年龄增长而递减的趋势，≥６５岁者ＡＦＰ值显著减低。提示ＨＢＶ感染与ＡＦＰ水平密切相关。

Alpha-fetoprotein(AFP)levals and HBV marks were measured in 108 patients with primary hepatocellular cancinoma uaing radio-immunoassay and ELISA method, respectively. Of 71 patients(68.5%) with the levels of AFP more than 20 μg/L, L, 65 patieots had above 100 μg/L. The median level. of AFP(505μg/L,range 20 to 2234μg/L) in HBsAg positive patients were significantly greater than those(20μg/L, range 20 to 383μg/L ) in HBsAg negative patients. The age in AFP peak levals consis- ted with the ages of the patients susceptible to primary hepatocellular cancinoma. This analysis shows that the levels of AFP closely correlate with the patients with HBV in- fection.