多不饱和脂肪酸对饲克山病病区粮大鼠体内磷酸肌酸激酶和α─羟丁酸脱氢酶活性的影响

Influence of polyunsaturates fatty acids on creatine kinase and α──hydroxybutyrate dehydrogenase levels in rats fed on cereals from Keshan disease areas

以非病区粮对照、克山病病区粮及其添加豆油（６０ｇ豆油／ｋｇ饲料）饲料喂养大鼠７０天，测定血浆中磷酸肌酸激酶、α──羟丁酸脱氢酶的含量。结果显示，饲料中添加富含多不饱和脂肪酸的豆油，可使大鼠血浆中这两种酶的含量显著增加（Ｐ＜０．０１）。说明，多不饱和脂肪酸长期负荷，能够降低实验动物体内的抗氧化能力。

Rats were fed on Keshan disease endemic or nonendemic grains for 70 days. The re-sults of creatine kinase(CK)and α── hydroxybutyrate dehydrogenase(α-HBDH)detected in plasmashowcd:when soybean oil(sufficient with polyunsaturates fatty acids,PUFAs)was added to either en-demic or nonendemic cereals(60 g soybean oil/Kg cereals),CK and α─HBDH of plasma increased(P<0.01).These results proved that PUFAs long─term overload could decrease the antioxidant abilityof rats fed on cereals from Keshan disease endemic areas.