大豆磷脂对克山病患者血浆和红细胞膜维生素E改变的影响

Influence of soyabean phosphol ipid on vitamin E level changes of plasma and erythrocyte membrane in patients with Keshan disease

通过对蛟河病区克山病及对照人群血浆和红细胞膜中ＶＥ的测定结果表明，虽然血浆中γ─Ｔｏｃｏ量克山病病区人群高于非病区人群，但是抗氧化能力最强的α─Ｔｏｃｏ和ＶＥ总量却是病区人群，尤其是克山病患者显著低于非病区人群；特别值得重视的是克山病患者红细胞膜中α─Ｔｏｃ０、γ─Ｔｏｃｏ和ＶＥ总量显著低于病区对照，亦低于非病区对照。证明克山病患者体内处于ＶＥ的缺乏状态。克山病患者口服３个月大豆ＰＬ后，红细胞膜中α─Ｔｏｃｏ和ＶＥ总量都有提高，达到病区对照水平。可见ＰＬ在克山病研究中的重要意义。

The VE contents of plasma and erythrocyte membrane in Keshan disease(KD)pa-tients from Jiaohe endemic area and control group were determinedThe fact is that α─Toco whichhas the most powerful antioxidative ability and the total VE contents of plasma in the people from KDendcmic area were lower than those from non ─endemic area,although theγ─Toco in the people fromendemic area were higher than those from non─endemic area. The α─Toco,γ─Toco and the totalVE amount of erythocyte membrane in KD patients were all lower than the control group of endcmicand non─endemic area. This restults indicated that KD patients were in the status of VE deficien-cv. After PL being taken orally for three months lthe levels of α─Toco and the total VE content oferythrocyte membrane were all increased to the levels of endemic control group.This results demon-strated that PL was of momentous significance in the study of KD.