红核内与调节心血管活动有关的受体

Receptors in red nucleus concerning its regulatory effect on cardiovascular activities

本文在４６只Ｗｉｓｔａｒ大鼠上证明向红核（ＲＮ）内注射微量γ──氨基丁酸（ＧＡＢＡ）和５──羟色胺（５ＨＴ）均能通过抑制ＲＮ，使心血管活动减弱：血压（ＢＰ）降低，心率（ＨＲ）减慢（Ｐ＜０．０５）；印防己毒素（ＰＴＸ）能有效地拮抗ＧＡＢＡ对ＲＮ的抑制效应（Ｐ＜０．０５）；而多巴胺（ＤＡ）则仅有降低ＢＰ作用（Ｐ＜０．０５），对ＨＲ无明显影响（Ｐ＞０．０５）。结果表明，ＲＮ能感受脑内ＧＡＢＡ、５ＨＴ和ＤＡ等递质系统活动的变化，对心血管活动进行紧张性调控。

In order to find the possible transmitting receptors in RN concerning its regulatory ef-fect on the cardiovascular activities the experiments were done by the method of injecting drugs intoRN in 46 Wistar rats. We found that y──aminobutyric acid(GABA)and 5──hydroxytryptamine(5HT)could decrease BP(P<0.01)and retard HR(P<0.05 ),picrotoxin(PTX)could antagonizepowerfully the inhibitory effects elicited by GABA(P<0.01),while dopamine(DA ) only decreasedBP(P<0. 01 ) but did not influence HR. These results showed that RN could accept the messagesfrom GABA,5HT and DA transmitting systems in the brain,and exert tonic regulatory role in the cardiovascular activities.