摘要
用辐射热甩尾反射测定大鼠痛阈的方法，观察并比较了东亚钳蝎毒素和吗啡的镇痛作用。结果表明：向侧脑室内注射２μＬ或肌肉注射０．０５μＬ、０．０１％蝎毒液的镇痛作用分别比相同给药途径、同浓度、同剂量吗啡的镇痛作用强，二者差异非常显著，Ｐ＜０．０ｌ。侧脑室内注射０．０３％蝎毒液２μＬ的镇痛作用比同浓度、同剂量吗啡的镇痛作用梢强，但无显著差异，Ｐ＞０．０５。蝎毒经肌肉注射后在较短的时间内即可使大鼠痛阈明显升高。证明蝎毒可通过血脑屏障进入中枢神经系统，产生镇痛作用。
The experimental results showed that the analgesic effect of 0.0l% BmK
venom in-jected either into lateral cerebral ventricle or intramuscularly was significantly
stronger than that ofmorphine under entirely the same condition,P<0.01. The analgesic effect of
0. 03% BmK venom in-jected into lateral cerebral ventricle was sliglitly stronger than that of
0.03% morphine,the differencebeing not so significant ,P<0. 05.The rise in pain threshold after
injecting BmK venom intramuscu-larly with a delay of only a few minutes indicated that the
BmK venom could permeate the blood-brain barrier into central nervous system to produce the
analgesic effect.
出处
《白求恩医科大学学报》
CSCD
1995年第3期260-262,共3页
Journal of Norman Bethune University of Medical Science
关键词
东亚钳蝎毒素
吗啡
镇痛作用
药理学
scorpion venom of Buthus martensii Karphine
injection into lateral
cerebral ventricle
intramuscular injection pain threshold
analgesic effect
