G－CSF对小儿恶性血液病及肿瘤化疗后作用的动态观察

DYNAMIC OBSERVATION ON THE EFFECT OF G-CSF FOR POST-CHEMOTHERAPY PATIENTS OF CHLIDHOOD MALIGNANT DISEASES

１０例小儿恶性肿瘤病人在接受强化疗后给予Ｇ－ＣＳＦ５－１０ｕｇ／ｋｇ／ｄ。９／１０例平均４天，１／１０例在１４天时白细胞总数上升至５．０×１０￣９／Ｌ以上，全部病例在停Ｇ－ＣＳＦ后４８～７２小时时出现第二次血象下跌。并观察到６／１０例在Ｇ－ＣＳＦ后平均第５天外周血出现幼稚细胞，３／７例骨髓粒系原始＋幼稚细胞不同程度升高，分别为２０％、２６％、８％，停用Ｇ－ＣＳＦ一周后未经任何化疗自然恢复正常，提示这些原始细胞来自正常的造血干细胞。

10 children with malignant diseases received G-CSF 5～ 10ug/kg/d after intensivechemotherapy. The absolute neutrophil count returned to 2.5×10/￣9/l in 4 days in 9 cases,another one in 14 days. All children had the second wave of WBC dropping 48～72 hours afterstopping G-CSF. Blast cells were found in peripheral blood in 6/10 children during G-CSFadministration. The blast cells in bone marrow were also increased in 3/7 cases(20%、26% and8% respectively),and returned to normal within 7 days after stopping using G-CSF. Thesesuggest that blast cells were from the normal hemotopoietic stem cells.