摘要
采用丹酰氯－聚酰胺薄层层析法定量检测６０例急性淋巴细胞白血病患儿红细胞内多胺水平改变。结果显示：（１）急性淋巴细胞白血病患儿红细胞多胺水平高于正常组，并且以精脒和精脒／精胺比值的变化最为显著（Ｐ＜０．００１）。（２）急性淋巴细胞白血病经治疗缓解后，红细胞多胺水平均有不同程度下降，其中以精脒下降幅度较大（Ｐ＜０．００１），但仍高于正常组（Ｐ＜０．００１），而精脒／精胺比值也下降，低于疗前组（Ｐ＜０．０５），但高于正常组（Ｐ＜０．０５）。结果提示急性淋巴细胞白血病患儿红细胞多胺的检测有助于白血病诊断、观察疗效和评估预后。
The value of polyamine in erythrocytes was studied in 60 patients
with acute lymphoblasticleukemia by a dansylchloride-polyamine thin layer chromatography.
The result showed that thepolyamine levels of erythrocyles in children with ALL elevated , and
compared with normalcontrols , levels of spermidine( Spd)and spermidine/spermine(Spd/Spm
)ratio significantlyincreased (P<0. 001).Spermidine concentrationP<0. 001)and the Spd/Spm
ratio(P<0.05)in erythrocytes of remmission was lower than ALL and higher than normal
controls. Theseresults indicated that the determination of erythrocytes in children with ALL may
be useful indiagnosis ,observation on the theropeutic effect and the prognosis.
出处
《白血病》
1995年第3期161-163,共3页
